Follitropin Receptor (FSH-R) (C-Term) antibody

Antigen: Follitropin Receptor (FSH-R)

Synonyms: GTHR-I, zfGTHR-I, FSHR, fshr-A, FSHRE, FSH-R, eFSHR, Fshr, fsh-r, fshr, LOC100304505

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350324

Additional Information

Alternative name: FSH Receptor (FSHR, Follicle-stimulating hormone receptor) (c-terminal region)

Swiss-Prot: P35378

Immunogen: A synthetic peptide from the c-terminal region of mouse FSH Receptor (FSHR, Follicle-stimulating hormone receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 96% identity with human sequence.

Format: Lyophilized

Description: FUNCTION: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Sertoli cells and ovarian granulosa cells. Also known as: FSH Receptor, FSHR, Follicle stimulating hormone receptor, FSH-R, Follitropin receptor.

Specificity: Appears to be specific for FSHR.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Huhtaniemi, Eskola, Pakarinen et al.: "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity." in: Molecular and cellular endocrinology, Vol. 88, Issue 1-3, pp. 55-66, 1993 (PubMed).

Tena-Sempere, Manna, Huhtaniemi: "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence." in: Biology of reproduction, Vol. 60, Issue 6, pp. 1515-27, 1999 (PubMed).

Allen, Achermann, Pakarinen et al.: "A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics." in: Human reproduction (Oxford, England), Vol. 18, Issue 2, pp. 251-6, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

De Leener, Montanelli, Van Durme et al.: "Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 2, pp. 555-62, 2006 (PubMed).