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GABARAP-L2 (AA 10-50) antibody

Reactivity: Human, Mouse, Rat IHC, WB Host: Sheep Polyclonal unconjugated
Catalog No. ABIN350325
  • Target
    GABARAP-L2
    Binding Specificity
    AA 10-50
    Reactivity
    Human, Mouse, Rat
    Host
    Sheep
    Clonality
    Polyclonal
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Specific for GABARAPL2.
    Immunogen
    A synthetic peptide from aa region 10-50 of human GABA(A) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
    Isotype
    IgG
  • Application Notes
    Use at a concentration of 10-50 µg/ml.
    The optimal working concentration should be determined by the end user.
    Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    GABARAP-L2
    Background
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association withGOSR1.
    Subcellular location: Golgi apparatus.
    Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Also known as: FLC3A, GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, General protein transport factor p16, MAP1 light chain 3-related protein.
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