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GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) (AA 10-50) antibody

Details for Product No. ABIN350326
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Antigen
Synonyms ATG8, ATG8C, GATE-16, GATE16, GEF-2, GEF2, Gef2, 0610012F20Rik, 2900019O08Rik, AI173605, zgc:92319, atg8, gate-16, gate16, gef2, GABARAPL2
Epitope
AA 10-50
(18), (8), (8), (6), (2), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(80), (19), (18), (13), (12), (1), (1), (1)
Host
Rabbit
(77), (2), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (10), (10), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(55), (53), (46), (10), (9), (6), (2), (1)
Pubmed 7 references available
Quantity 100 µL
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Catalog No. ABIN350326
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from AA 10-50 of human GABA(A) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Specific for WFS1.
Purification whole serum
Alternative Name GABA(A) receptor associated protein like 2 (GABARAPL2, ATG8, GATE16)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association withGOSR1.
Subcellular location: Golgi apparatus.
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Also known as: FLC3A, GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, General protein transport factor p16, MAP1 light chain 3-related protein.
UniProt P56695
Application Notes Use at a dilution of 1 : 200 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Okazaki, Yan, Yuasa et al.: "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation." in: Brain research. Molecular brain research, Vol. 85, Issue 1-2, pp. 1-12, 2001 (PubMed).

Tanida, Tanida-Miyake, Nishitani et al.: "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 256-62, 2002 (PubMed).

Scherz-Shouval, Sagiv, Shorer et al.: "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14053-8, 2003 (PubMed).

Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Sou, Tanida, Komatsu et al.: "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3017-24, 2006 (PubMed).

Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350326
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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