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GBB2 (Transducin beta chain 2, GNB2, G protein subunit beta-2) (N-Term) antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|9 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the n-terminal part of human, rat, mouse, xenopus, zebra fish Transducin beta chain 2 (GBB2, GNB2, G protein subunit beta-2) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18. Also known as: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2, G protein subunit beta-2, GNB2.|
|Specificity||Appears to be specific for GBB2.|
|Application Notes||IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Fong, Amatruda, Birren et al.: "Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 11, pp. 3792-6, 1987 (PubMed).
Gao, Gilman, Robishaw: "A second form of the beta subunit of signal-transducing G proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 17, pp. 6122-5, 1987 (PubMed).
Williams, Schultz, Kopf: "G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development." in: Molecular reproduction and development, Vol. 44, Issue 3, pp. 315-23, 1997 (PubMed).
Glöckner, Scherer, Schattevoy et al.: "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes." in: Genome research, Vol. 8, Issue 10, pp. 1060-73, 1998 (PubMed).
Arnot, Stotz, Jarvis et al.: "Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms." in: The Journal of physiology, Vol. 527 Pt 2, pp. 203-12, 2000 (PubMed).
Wilson, Riemer, Martindale et al.: "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." in: Nucleic acids research, Vol. 29, Issue 6, pp. 1352-65, 2001 (PubMed).
Kitanaka, Wang, Kitanaka et al.: "Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 12, Issue 5-6, pp. 345-54, 2002 (PubMed).
Niu, Profirovic, Pan et al.: "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production." in: Circulation research, Vol. 93, Issue 9, pp. 848-56, 2003 (PubMed).
Ballif, Carey, Sunyaev et al.: "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." in: Journal of proteome research, Vol. 7, Issue 1, pp. 311-8, 2008 (PubMed).