GBB3 (Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3) (N-Term) antibody

Antigen: GBB3 (Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3)

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350333

Additional Information

UniProt: P16520

Immunogen: A synthetic peptide from the n-terminal of human GBB3 (Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat and mouse.

Format: Lyophilized

Description: FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. Also known as: Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3.

Specificity: Appears to be specific for GBB3.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 5000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Levine, Smallwood, Moen et al.: "Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 6, pp. 2329-33, 1990 (PubMed).

Ansari-Lari, Muzny, Lu et al.: "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13." in: Genome research, Vol. 6, Issue 4, pp. 314-26, 1996 (PubMed).

Ansari-Lari, Shen, Muzny et al.: "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination." in: Genome research, Vol. 7, Issue 3, pp. 268-80, 1997 (PubMed).

Rosskopf, Busch, Manthey et al.: "G protein beta 3 gene: structure, promoter, and additional polymorphisms." in: Hypertension, Vol. 36, Issue 1, pp. 33-41, 2000 (PubMed).