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Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3) (AA 2-50) antibody

Details for Product No. ABIN350333, Supplier: Log in to see
Antigen
  • MGC68913
  • MGC130764
  • gnb3
  • zgc:73058
  • zgc:77780
  • wu:fk54b04
  • Gnb-3
Epitope
AA 2-50
18
13
3
2
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
66
38
38
4
4
2
2
Host
Rabbit
41
20
5
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
32
26
22
10
10
5
1
1
Supplier
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Immunogen A synthetic peptide from aa region 2-50 of human GNB3 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for GBB3.
Purification Whole serum
Alternative Name GNB3 (GNB3 Antibody Abstract)
Background Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in varioustransmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Also known as: Transducin beta chain 3, GNB3, Guanine nucleotide binding protein subunit beta-3.
Research Area Cancer
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Rosskopf, Busch, Manthey et al.: "G protein beta 3 gene: structure, promoter, and additional polymorphisms." in: Hypertension, Vol. 36, Issue 1, pp. 33-41, 2000 (PubMed).

Ansari-Lari, Shen, Muzny et al.: "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination." in: Genome research, Vol. 7, Issue 3, pp. 268-80, 1997 (PubMed).

Ansari-Lari, Muzny, Lu et al.: "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13." in: Genome research, Vol. 6, Issue 4, pp. 314-26, 1996 (PubMed).

Levine, Smallwood, Moen et al.: "Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 6, pp. 2329-33, 1990 (PubMed).

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