GBLP (RACK1) (Internal Region) antibody

Details for Product No. ABIN350336
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Internal Region
Human, Rat (Rattus), Mouse (Murine)
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350336
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the internal region of human GBLP (RACK1, GNB2L1, Receptor for activated C kinase) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse and xenopus.
Specificity Specific for KCNMB2.
Purification whole serum
Background Function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
Subcellular location: Cell membrane. Note: Located on plasma membrane of neuroblastoma NMB7 cells. Also known as: Guanine nucleotide-binding protein subunit beta-like protein 12.3, Receptor of activated protein kinase C 1, RACK1, Receptor for activated C kinase, Guanine nucleotide-binding protein subunit beta-2-like 1, GNB2L1.
UniProt Q9CZM9
Research Area Neurology
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Watson, Katz, Simon: "A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C." in: The Journal of biological chemistry, Vol. 269, Issue 35, pp. 22150-6, 1994 (PubMed).

Watson, Aragay, Slepak et al.: "A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina." in: The Journal of biological chemistry, Vol. 271, Issue 45, pp. 28154-60, 1996 (PubMed).

Jones, Lombardi, Cockett: "Cloning and tissue distribution of the human G protein beta 5 cDNA." in: Biochimica et biophysica acta, Vol. 1402, Issue 3, pp. 288-91, 1998 (PubMed).

Betty, Harnish, Rhodes et al.: "Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain." in: Neuroscience, Vol. 85, Issue 2, pp. 475-86, 1999 (PubMed).

Krispel, Chen, Melling et al.: "RGS expression rate-limits recovery of rod photoresponses." in: Neuron, Vol. 51, Issue 4, pp. 409-16, 2006 (PubMed).

back to top