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Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (Internal Region) antibody

Details for Product No. ABIN350336, Supplier: Log in to see
Antigen
  • MGC53289
  • GNB2L1
  • AL033335
  • GB-like
  • Gnb2-rs1
  • Rack1
  • p205
  • RACK1
  • H12.3
  • HLC-7
  • PIG21
  • rack1
  • wu:fb80d08
  • wu:fk65d12
  • gnb2-rs1
  • h12.3
  • hlc-7
  • pig21
  • C12-3
  • c12.3
Epitope
Internal Region
21
9
8
3
2
2
2
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
71
28
25
6
5
4
3
3
2
2
2
1
1
Host
Rabbit
64
6
4
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
2
2
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
59
28
28
14
6
6
2
2
2
1
1
1
Supplier
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Immunogen A synthetic peptide from the internal region of human RACK1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse and xenopus.
Specificity Specific for GBLP.
Purification Whole serum
Alternative Name RACK1 (GNB2L1 Antibody Abstract)
Background Function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.
Subcellular location: Cell membrane. Note: Located on plasma membrane of neuroblastoma NMB7 cells. Also known as: Guanine nucleotide-binding protein subunit beta-like protein 12.3, Receptor of activated protein kinase C 1, RACK1, Receptor for activated C kinase, Guanine nucleotide-binding protein subunit beta-2-like 1, GNB2L1.
Research Area Kinases/Phosphatases
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Krispel, Chen, Melling et al.: "RGS expression rate-limits recovery of rod photoresponses." in: Neuron, Vol. 51, Issue 4, pp. 409-16, 2006 (PubMed).

Betty, Harnish, Rhodes et al.: "Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain." in: Neuroscience, Vol. 85, Issue 2, pp. 475-86, 1999 (PubMed).

Jones, Lombardi, Cockett: "Cloning and tissue distribution of the human G protein beta 5 cDNA." in: Biochimica et biophysica acta, Vol. 1402, Issue 3, pp. 288-91, 1998 (PubMed).

Watson, Aragay, Slepak et al.: "A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina." in: The Journal of biological chemistry, Vol. 271, Issue 45, pp. 28154-60, 1996 (PubMed).

Watson, Katz, Simon: "A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C." in: The Journal of biological chemistry, Vol. 269, Issue 35, pp. 22150-6, 1994 (PubMed).

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