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Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) (AA 170-220) antibody

Details for Product No. ABIN350337
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Antigen
Synonyms 4930406E12Rik, AU016030, AW209092, fb33h10, im:6912200, wu:fb33h10, zgc:101044
Epitope
AA 170-220
(15), (8), (3), (3), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(38), (17), (13), (13), (12), (12), (3)
Host
Rabbit
(36), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(28), (18), (10), (8), (5), (4), (3), (1), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350337
454.67 $
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Immunogen A synthetic peptide from aa region 170-220 of the GAT domain of human GGA1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many other species including rat, mouse, xenopus, zebrafish.
Specificity Specific for GGA1.
Purification Whole serum
Alternative Name GGA1
Background Function: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Subcellular location: Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein. Endosome membrane, Peripheral membrane protein.
Tissue specificity: Ubiquitously expressed. Also known as: ADP-ribosylation factor-binding protein GGA1, Golgi-localized, gamma ear-containing, ARF-binding protein 1, Gamma-adaptin-related protein 1.
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

DellAngelica, Puertollano, Mullins et al.: "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex." in: The Journal of cell biology, Vol. 149, Issue 1, pp. 81-94, 2000 (PubMed).

Boman, Zhang, Zhu et al.: "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi." in: Molecular biology of the cell, Vol. 11, Issue 4, pp. 1241-55, 2000 (PubMed).

He, Zhu, Koelsch et al.: "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins." in: Biochemistry, Vol. 42, Issue 42, pp. 12174-80, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

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