ADP-Ribosylation Factor-Binding Protein GGA2 (GAT domain) antibody

Antigen: ADP-Ribosylation Factor-Binding Protein GGA2

Synonyms: mKIAA1080, 1200007E24Rik

Epitope: GAT domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350339

Additional Information

Alternative name: GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (GAT domain)

Swiss-Prot: Q6P5E6

Immunogen: A synthetic peptide from the GAT domain of mouse GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.

Format: Lyophilized

Description: FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Also known as: ADP-ribosylation factor-binding protein GGA2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; Gamma-adaptin-related protein 2.

Specificity: Appears to be specific for GGA2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Okazaki, Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 10, Issue 4, pp. 167-80, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).