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G-Protein Signaling 19 (RGS19, G-alpha-Interacting Protein, GAIP, GNAI3IP,RGSGAIP) Regulator antibody

Details for Product No. ABIN350353
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Antigen
Reactivity
Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350353
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from human Regulator of G-protein signaling 19 (RGS19) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for Optineurin.
Purification whole serum
Background G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Subcellular location: Membrane, Lipid-anchor.
Tissue specificity: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Also known as: RGS19, G-alpha-interacting protein, GAIP, GNAI3IP, RGSGAIP.
UniProt Q8K3K8
Research Area Neurology, Innate Immunity, Cytokines
Application Notes Use at a dilution of 1:300 to 1: 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General De Vries, Mousli, Wurmser et al.: "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 25, pp. 11916-20, 1996 (PubMed).

De Vries, Elenko, Hubler et al.: "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 26, pp. 15203-8, 1997 (PubMed).

Wang, Ducret, Tu et al.: "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily." in: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 26014-25, 1998 (PubMed).

de Alba, De Vries, Farquhar et al.: "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling." in: Journal of molecular biology, Vol. 291, Issue 4, pp. 927-39, 1999 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350353
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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