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G-protein signaling 19 (RGS19, G-alpha-interacting protein, GAIP, GNAI3IP,RGSGAIP) Regulator antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide as a part of human, rat, mouse Regulator of G-protein signaling 19 (RGS19, G-alpha-interacting protein, GAIP, GNAI3IP,RGSGAIP) conjugated to an immunogenic carrier protein has been used as the immunogen.|
|Description||G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP. Also known as: RGS19, G-alpha-interacting protein, GAIP, GNAI3IP, RGSGAIP.|
|Specificity||Appears to be specific for RGS19.|
|Application Notes||IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
De Vries, Mousli, Wurmser et al.: "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 25, pp. 11916-20, 1996 (PubMed).
De Vries, Elenko, Hubler et al.: "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 26, pp. 15203-8, 1997 (PubMed).
Wang, Ducret, Tu et al.: "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily." in: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 26014-25, 1998 (PubMed).
de Alba, De Vries, Farquhar et al.: "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling." in: Journal of molecular biology, Vol. 291, Issue 4, pp. 927-39, 1999 (PubMed).
Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).