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HCN1 antibody (AA 400-450)

HCN1 Reactivity: Human WB, IHC Host: Sheep Polyclonal unconjugated
Catalog No. ABIN350360
  • Target See all HCN1 Antibodies
    HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))
    Binding Specificity
    • 14
    • 13
    • 9
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 400-450
    Reactivity
    • 39
    • 25
    • 16
    • 1
    • 1
    Human
    Host
    • 38
    • 17
    • 1
    • 1
    Sheep
    Clonality
    • 40
    • 17
    Polyclonal
    Conjugate
    • 27
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HCN1 antibody is un-conjugated
    Application
    • 46
    • 36
    • 22
    • 16
    • 11
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for HCN1.
    Cross-Reactivity
    Human, Mouse, Rat
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from AA 400-450 of human HCN1 conjugated to an immunogenic carrier protein was used as the antigen.
    Isotype
    IgG
    Top Product
    Discover our top product HCN1 Primary Antibody
  • Application Notes
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))
    Alternative Name
    HCN1 (HCN1 Products)
    Synonyms
    BCNG-1 antibody, BCNG1 antibody, HAC-2 antibody, Bcng1 antibody, C630013B14Rik antibody, HAC2 antibody, hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody, hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 antibody, hyperpolarization-activated, cyclic nucleotide-gated K+ 1 antibody, hcn1 antibody, HCN1 antibody, Hcn1 antibody
    Background
    FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN2. Interacts with KCNE2. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,HCN Channels,Brain cyclic nucleotide-gated channel 1, BCNG-1, BCNG1, HAC-2, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
    UniProt
    O60741
    Pathways
    Asymmetric Protein Localization
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