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Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) (C-Term) antibody

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Synonyms SSS2, HAC4, Bcng3, Hcn3
(45), (20), (16), (2), (1), (1), (1), (1)
(49), (30), (25), (2)
(43), (13), (1)
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (45), (39), (38), (8), (4), (2), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 100 μL
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Immunogen A synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for HCN4.
Purification Whole serum
Alternative Name HCN4 (HCN4 Antibody Abstract)
Background Function: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. DISEASE: Defects in HCN4 are a cause of autosomal dominant sick sinus syndrome (SSS), also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder.
Miscellaneous: Inhibited by extracellular cesium ions. Also known as: HCN4.
Research Area Cardiovascular
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Milanesi, Baruscotti, Gnecchi-Ruscone et al.: "Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel." in: The New England journal of medicine, Vol. 354, Issue 2, pp. 151-7, 2006 (PubMed).

Ueda, Nakamura, Hayashi et al.: "Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia." in: The Journal of biological chemistry, Vol. 279, Issue 26, pp. 27194-8, 2004 (PubMed).

Seifert, Scholten, Gauss et al.: "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 16, pp. 9391-6, 1999 (PubMed).

Ludwig, Zong, Stieber et al.: "Two pacemaker channels from human heart with profoundly different activation kinetics." in: The EMBO journal, Vol. 18, Issue 9, pp. 2323-9, 1999 (PubMed).

Catalog No. ABIN350362
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