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Details for Product No. ABIN350366

Hepcidin Antimicrobial Peptide (HAMP) (Prodomain) antibody

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Antigen
Synonyms HEPC, HFE2B, LEAP1, PLTR, Hepc, Hamp1, Hepc1, hepcidin, Hepcidin, HAMP
Epitope
»Alternatives Prodomain
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350366
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from internal region of mouse Hepcidin (HAMP) conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for Hepcidin.
Purity whole serum
Alternative Name Hepcidin (HAMP)
Background Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
Subcellular location: Secreted.
Tissue specificity: Highly expressed in the liver and to a much lesser extent in the heart. Also known as: Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1.
UniProt Q9EQ21
Application Notes IHC, WB. Use at a dilution of 1:100 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Pigeon, Ilyin, Courselaud et al.: "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7811-9, 2001 (PubMed).

Nicolas, Bennoun, Devaux et al.: "Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 15, pp. 8780-5, 2001 (PubMed).

Alternatives for antigen "Hepcidin Antimicrobial Peptide (HAMP)", type "Antibodies"
Hosts (43), (8), (6)
Reactivities (47), (12)
Applications (53), (39), (21), (11), (4), (4), (3), (2), (2), (2), (2), (2), (1)
Conjugates (4)
Epitopes (11), (9), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1)
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