Hepcidin Antimicrobial Peptide (HAMP) antibody

Details for Product No. ABIN350366
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Antigen
Synonyms HEPC, HFE2B, LEAP1, PLTR, Hepc, Hamp1, Hepc1, hepcidin, Hepcidin, HAMP
Reactivity
Mouse (Murine)
(45), (17), (5), (2), (2), (2), (1)
Host
Rabbit
(47), (12), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(58), (45), (21), (18), (14), (7), (6), (3), (3), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN350366
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from pro region of mouse Hepcidin (HAMP) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for P2RY4.
Purification whole serum
Alternative Name Hepcidin (HAMP)
Background Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity.
Subcellular location: Secreted.
Tissue specificity: Highly expressed in the liver and to a much lesser extent in the heart. Also known as: Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1.
UniProt Q9JJS7
Application Notes Use at a dilution of 1:100 to 1: 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Pigeon, Ilyin, Courselaud et al.: "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7811-9, 2001 (PubMed).

Nicolas, Bennoun, Devaux et al.: "Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 15, pp. 8780-5, 2001 (PubMed).

Hosts (47), (12), (4), (1)
Reactivities (45), (17), (5), (2), (2), (2), (1)
Applications (58), (45), (21), (18), (14), (7), (6), (3), (3), (2), (2), (2), (1)
Conjugates (4), (2)
Epitopes (11), (9), (5), (2), (2), (2), (2), (1), (1), (1)
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