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Details for Product No. ABIN350368

Hepcidin Antimicrobial Peptide (HAMP) (Prodomain) antibody

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Antigen
Synonyms HEPC, HFE2B, LEAP1, PLTR, Hepc, Hamp1, Hepc1, hepcidin, Hepcidin, HAMP
Epitope
»Alternatives Prodomain
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350368
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from n-terminal of human Hepcidin (HAMP) conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for Hepcidin.
Purity whole serum
Alternative Name Hepcidin (HAMP)
Background Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
Subcellular location: Secreted.
Tissue specificity: Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. Also known as: Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1.
UniProt P81172
Application Notes IHC, WB. Use at a dilution of 1:100 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Comment

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. Expiry Date: 12 months after reconstitution Transportation: This item will be shipped to you at ambient temperature in a lyophilised form.

Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Krause, Neitz, Maegert et al.: "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity." in: FEBS letters, Vol. 480, Issue 2-3, pp. 147-50, 2000 (PubMed).

Park, Valore, Waring et al.: "Hepcidin, a urinary antimicrobial peptide synthesized in the liver." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7806-10, 2001 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

Delatycki, Allen, Gow et al.: "A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis." in: Clinical genetics, Vol. 65, Issue 5, pp. 378-83, 2004 (PubMed).

Alternatives for antigen "Hepcidin Antimicrobial Peptide (HAMP)", type "Antibodies"
Hosts (43), (8), (6)
Reactivities (46), (13)
Applications (53), (39), (21), (11), (4), (4), (3), (2), (2), (2), (2), (2), (1)
Conjugates (4)
Epitopes (11), (9), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1)
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