Histone Deacetylase 1 (HDAC1) (Internal Region) antibody

Details for Product No. ABIN350374
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Antigen
Synonyms
HD1, RPD3, Hdac1, Gm1824, EG15181, Hdac1-ps, ENSMUSG00000061062, Rpd3, GB14706, hdac1, rpd3, yaf1, gon-10, hdac1-b, rpd3l1, ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1 ... show more
HD1, RPD3, Hdac1, Gm1824, EG15181, Hdac1-ps, ENSMUSG00000061062, Rpd3, GB14706, hdac1, rpd3, yaf1, gon-10, hdac1-b, rpd3l1, ARABIDOPSIS HISTONE DEACETYLASE 1, ARABIDOPSIS HISTONE DEACETYLASE 19, ATHD1, ATHDA19, ATRPD3A, F20D10.250, F20D10_250, HDA1, HDA19, HISTONE DEACETYLASE, HISTONE DEACETYLASE 19, HISTONE DEACETYLASE19, RPD3A, histone deacetylase 1, CG7471, DHDAC1, DRpd3, DmHDAC1, Dmel\\CG7471, E(var)3-64BC, HDAC, HDAC-1, HDAC1, Rpd3/HDAC, Su(var)3-26, Su(var)326, Su(var)328, dHDAC-1, dHDAC1, dRPD3, dRpd3, dmHDA401, drpd3, l(3)04556, l(3)64Cc, rpd[3], GON-10, RPD3L1, MommeD5, chunp6919, hdac-1, mp:zf637-2-001987, wu:fb19h11, wu:fi06f03, zgc:101582, zgc:65818, hdac1b show less
Epitope
Internal Region
(63), (33), (31), (17), (16), (9), (8), (8), (7), (7), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(289), (147), (143), (43), (41), (37), (16), (12), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(246), (52), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(238), (130), (72), (67), (66), (40), (32), (32), (9), (3), (3), (3), (3), (2), (1)
Pubmed 7 references available
Quantity 100 µL
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Catalog No. ABIN350374
454.67 $
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Immunogen A synthetic peptide from internal region of human Histone deacetylase 1 (HDAC1, RPD3L1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and moue.
Specificity Specific for HDAC1.
Purification Whole serum
Alternative Name HDAC1
Background Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Catalytic activity: Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. Also known as: HDAC1, RPD3L1.
Research Area Cardiovascular, Hypertrophy, Wnt, DNA/RNA, Transcription Factors
Application Notes A dilution of 1 : 300 to 1 : 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Taunton, Hassig, Schreiber: "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p." in: Science (New York, N.Y.), Vol. 272, Issue 5260, pp. 408-11, 1996 (PubMed).

Furukawa, Kawakami, Sudo et al.: "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae." in: Cytogenetics and cell genetics, Vol. 73, Issue 1-2, pp. 130-3, 1996 (PubMed).

Cai, Yan-Neale, Cueto et al.: "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27909-16, 2000 (PubMed).

Wei, Hu, Chandra et al.: "Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 40782-7, 2001 (PubMed).

Melhuish, Gallo, Wotton: "TGIF2 interacts with histone deacetylase 1 and represses transcription." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32109-14, 2001 (PubMed).

Pflum, Tong, Lane et al.: "Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47733-41, 2001 (PubMed).

Barrett, Santangelo, Tan et al.: "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases." in: International journal of cancer. Journal international du cancer, Vol. 121, Issue 2, pp. 265-75, 2007 (PubMed).

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