Huntingtin antibody (HTT) (AA 1150-1200)

Details for Product anti-HTT Antibody No. ABIN350377, Supplier: Log in to see
Antigen
  • HTT
  • hd
  • ZHD
  • CG9995
  • Dmel\\CG9995
  • HD
  • Hsap\\HD
  • Htt
  • dHtt
  • dhtt
  • SLC6A4
  • huntington
  • it15
  • htt
  • IT15
  • AI256365
  • C430023I11Rik
  • Hd
  • Hdh
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • huntingtin
  • SLC6A4
  • LOC100216476
  • htt
  • Htt
  • HTT
  • HDH
Alternatives
anti-Rat (Rattus) Huntingtin antibody for ELISA
Epitope
AA 1150-1200
15
12
12
8
8
7
5
5
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine)
154
102
61
13
6
2
2
2
1
1
1
Host
Rabbit
81
77
3
1
Clonality
Polyclonal
Conjugate
This Huntingtin antibody is un-conjugated
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
133
75
72
37
26
25
23
17
13
8
4
3
2
1
Options
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Immunogen A synthetic peptide from aa region 1150-1200 of rat Huntingtin conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 87% identity with mouse and human sequences.
Isotype IgG
Specificity Specific for Huntingtin.
Alternative Name Huntingtin (HTT Antibody Abstract)
Background Function: May play a role in microtubule-mediated transport or vesicle function.
Subcellular location: Cytoplasm. Nucleus.
Tissue specificity: Expressed to a high degree in all the regions of the brain of adults and in meiotic cells of the testis. In addition, very low levels are detected in various non-neuronal tissues (heart, muscle, liver, lung and kidney).
Developmental stage: Identified at high levels in neuronal tissues of embryos as early as day 14.5. This expression remains constant in all further development stages (up to the adult). On the other hand the expression in non-neuronal tissues is down-regulated from stage 17.5 day old embryos. Also known as: Huntington disease protein homolog, Htt, HD protein homolog.
Research Area Neurology, Virology
Pathways PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Schmitt, Baechner, Megow, Henklein, Hameister, Epplen, Riess: "Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development." in: Human molecular genetics, Vol. 4, Issue 7, pp. 1173-82, 1996 (PubMed).

Strong, Tagle, Valdes, Elmer, Boehm, Swaroop, Kaatz, Collins, Albin: "Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues." in: Nature genetics, Vol. 5, Issue 3, pp. 259-65, 1994 (PubMed).