Potassium Voltage-Gated Channel Subfamily A Member 2 (KCNA2) (C-Term) antibody

Antigen: Potassium Voltage-Gated Channel Subfamily A Member 2 (KCNA2)

Synonyms: BK2, NGK1

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350378

Additional Information

Alternative name: KCNA2 (Potassium voltage gated channel subfamily A member 2, Kv1.2) (c-terminal region)

Swiss-Prot: P63142

Immunogen: A synthetic peptide from the c-terminal region of rat KCNA2 (Potassium voltage gated channel subfamily A member 2, Kv1.2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse, human and chicken.

Format: Lyophilized

Description: FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: RBK2, RCK5, RAK, Potassium voltage-gated channel subfamily A member 2, Voltage gated potassium channel subunit Kv1.2, Voltage-gated potassium channel subunit Kv1.2.

Specificity: Appears to be specific for KCNA2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Paulmichl, Nasmith, Hellmiss et al.: "Cloning and expression of a rat cardiac delayed rectifier potassium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 17, pp. 7892-5, 1991 (PubMed).

Stuehmer, Ruppersberg, Schroeter et al.: "Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain." in: The EMBO journal, Vol. 8, Issue 11, pp. 3235-44, 1989 (PubMed).

Kim, Niethammer, Rothschild et al.: "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases." in: Nature, Vol. 378, Issue 6552, pp. 85-8, 1995 (PubMed).

Minor, Lin, Mobley et al.: "The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel." in: Cell, Vol. 102, Issue 5, pp. 657-70, 2000 (PubMed).

Long, Campbell, Mackinnon: "Crystal structure of a mammalian voltage-dependent Shaker family K+ channel." in: Science (New York, N.Y.), Vol. 309, Issue 5736, pp. 897-903, 2005 (PubMed).