Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (internal) antibody

Antigen: Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3)

Synonyms: MK3, HGK5, HLK3, PCN3, HPCN3, KV1.3, HUKIII, Mk-3, Kv1.3, Kca1-3, kv1.3, Kv1.3B, kcna3b-a, cKv1.1

Epitope: internal

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350379

Additional Information

Alternative name: KCNA3 (Potassium voltage-gated channel subfamily A member 3, Kv1.3) (internal region)

Swiss-Prot: P22001

Immunogen: A synthetic peptide from the internal part of human KCNA3 (Potassium voltage-gated channel subfamily A member 3, Kv1.3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 91% with rat and mouse sequence.

Format: Lyophilized

Description: Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Subcellular location: Membrane; Multi-pass membrane protein. Also known as: Voltage-gated potassium channel subunit Kv1.3, HPCN3, HGK5, HuKIII, HLK3, HGK5, Potassium voltage-gated channel subfamily A member 3.

Specificity: Appears to be specific for KCNA3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Attali, Romey, Honorue et al.: "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes." in: The Journal of biological chemistry, Vol. 267, Issue 12, pp. 8650-7, 1992 (PubMed).

Cai, Osborne, North et al.: "Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel." in: DNA and cell biology, Vol. 11, Issue 2, pp. 163-72, 1992 (PubMed).

Philipson, Hice, Schaefer et al.: "Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 1, pp. 53-7, 1991 (PubMed).

Folander, Douglass, Swanson: "Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1." in: Genomics, Vol. 23, Issue 1, pp. 295-6, 1995 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).