Voltage-Gated Potassium Channel, Subfamily H, Member 2 (KCNH2) (C-Term) antibody

Antigen: Voltage-Gated Potassium Channel, Subfamily H, Member 2 (KCNH2)

Synonyms: ERG1, HERG, LQT2, SQT1, HERG1, Kv11.1, KCNH2, cerg, derg, erg1, MGC143108

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350380

Additional Information

Alternative name: KCNH2 (Potassium voltage-gated channel subfamily H member 2, Kv11.1) (c-terminal region)

Swiss-Prot: Q12809

Immunogen: A synthetic peptide from the c-terminal region of human KCNH2 (Potassium voltage-gated channel subfamily H member 2, Kv11.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and rat.

Format: Lyophilized

Description: FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Isoform 1 is expressed in heart, brain and testis and at low levels in lung. Isoform 3 is expressed predominantly in heart. The expression of isoform 2 is low in all tissues tested. Also known as: Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related gene potassium channel 1, H-ERG, Erg1, Ether-a-go-go-related protein 1, Eag-related protein 1, eag homolog, ERG, ERG1, HERG, HERG1.

Specificity: Appears to be specific for KCNH2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Lees-Miller, Kondo, Wang et al.: "Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts." in: Circulation research, Vol. 81, Issue 5, pp. 719-26, 1997 (PubMed).

London, Trudeau, Newton et al.: "Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current." in: Circulation research, Vol. 81, Issue 5, pp. 870-8, 1997 (PubMed).