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Details for Product No. ABIN350381

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) (C-Term) antibody

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Antigen
Synonyms ERG, gp-erg, ERG1, HERG, LQT2, SQT1, HERG1, Kv11.1, KCNH2, erg, LQT, Lqt2, M-erg, Merg1, merg1a, merg1b, AI326795, cerg, derg, erg1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350381
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human KCNH2 (Potassium voltage-gated channel subfamily H member 2, Kv11.1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for p75NTR.
Purity IgG
Alternative Name KCNH2 (Potassium voltage-gated channel subfamily H member 2, Kv11.1)
Background Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Isoform 1 is expressed in heart, brain and testis and at low levels in lung. Isoform 3 is expressed predominantly in heart. The expression of isoform 2 is low in all tissues tested. Also known as: Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related gene potassium channel 1, H-ERG, Erg1, Ether-a-go-go-related protein 1, Eag-related protein 1, eag homolog, ERG, ERG1, HERG, HERG1.
UniProt P07174
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Lees-Miller, Kondo, Wang et al.: "Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts." in: Circulation research, Vol. 81, Issue 5, pp. 719-26, 1997 (PubMed).

London, Trudeau, Newton et al.: "Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current." in: Circulation research, Vol. 81, Issue 5, pp. 870-8, 1997 (PubMed).

Alternatives for antigen "Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2)", type "Antibodies"
Hosts (53), (1)
Reactivities (47), (18), (18), (17), (12), (1)
Applications (41), (16), (16), (10), (9), (8), (7), (4), (3), (3)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (8), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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