Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10) (AA 330-379) antibody

Details for Product No. ABIN350385
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Antigen
Synonyms kir1.2, kir4.1, birk-10, MGC145926, BIR10, BIRK-1, Kir1.2, Kir4.1, BIRK-10, KCNJ13-PEN, KIR1.2, KIR4.1, SESAME
Epitope
AA 330-379
(7), (6), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(33), (18), (18), (13), (13), (13), (13)
Host
Rabbit
(28), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(23), (13), (11), (10), (3), (3)
Pubmed 5 references available
Quantity 500 μg
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Catalog No. ABIN350385
454.67 $
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Immunogen A synthetic peptide from aa region 330-379 of human KCNJ10 conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for KCNJ10.
Alternative Name KCNJ10
Background Function: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 10, Potassium channel, inwardly rectifying subfamily J member 10, Inward rectifier K(+) channel Kir1.2, ATP-dependent inwardly rectifying potassium channel Kir4.1.
Research Area Neurology
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Shuck, Piser, Bock et al.: "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 586-93, 1997 (PubMed).

Kurschner, Mermelstein, Holden et al.: "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins." in: Molecular and cellular neurosciences, Vol. 11, Issue 3, pp. 161-72, 1998 (PubMed).

Schoots, Wilson, Ethier et al.: "Co-expression of human Kir3 subunits can yield channels with different functional properties." in: Cellular signalling, Vol. 11, Issue 12, pp. 871-83, 2000 (PubMed).

Li, Head, Timpe: "Identification of an inward rectifier potassium channel gene expressed in mouse cortical astrocytes." in: Glia, Vol. 33, Issue 1, pp. 57-71, 2001 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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