Potassium Inwardly-Rectifying Channel, Subfamily J, Member 12 (KCNJ12) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350387
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms IRK-2, IRK2, KCNJN1, Kir2.2, Kir2.2v, hIRK, hIRK1, hkir2.2x, kcnj12x, Kir2.1, IRK, KIR2.2, MB-IRK2
Cytoplasmic Domain
(31), (23), (16), (16), (5), (2), (1), (1), (1)
(52), (51), (32), (2), (1), (1)
(43), (34)
(4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(73), (39), (36), (28), (16), (3), (3), (2)
Pubmed 5 references available
Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ12 (KCNJN1, Kir2.2, IRK2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for KCNJ12.
Purification Whole serum
Alternative Name KCNJ12 (KCNJ12 Antibody Abstract)
Background Function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 12, Potassium channel, inwardly rectifying subfamily J member 12, Inward rectifier K(+) channel Kir2.2, Kir2.2v, IRK2, KCNJN1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Kaibara, Ishihara, Doi et al.: "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes." in: FEBS letters, Vol. 531, Issue 2, pp. 250-4, 2002 (PubMed).

Gallagher, Forget: "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1339-48, 1998 (PubMed).

Namba, Inagaki, Gonoi et al.: "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2." in: FEBS letters, Vol. 386, Issue 2-3, pp. 211-4, 1996 (PubMed).

Wible, De Biasi, Majumder et al.: "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium." in: Circulation research, Vol. 76, Issue 3, pp. 343-50, 1995 (PubMed).

Catalog No. ABIN350387
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?