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KCNJ15 (KCNJ14, Kir4.2) (Cytoplasmic Domain) antibody
Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the cytoplasmic domain of human KCNJ15 (KCNJ14, Kir4.2) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 15, Potassium channel, inwardly rectifying subfamily J member 15, Inward rectifier K(+) channel Kir4.2, KCNJ14, Kir4.2.|
|Specificity||Appears to be specific for KCNJ15.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Shuck, Piser, Bock et al.: "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 586-93, 1997 (PubMed).
Gosset, Ghezala, Korn et al.: "A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)." in: Genomics, Vol. 44, Issue 2, pp. 237-41, 1997 (PubMed).
Kurschner, Mermelstein, Holden et al.: "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins." in: Molecular and cellular neurosciences, Vol. 11, Issue 3, pp. 161-72, 1998 (PubMed).
Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).