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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5 (KCNJ5) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350398
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Antigen
Synonyms CIR, cir, xcir, GIRK4, KATP1, KIR3.4, LQT13, Kir3.4
Epitope
Cytoplasmic Domain
(10), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(39), (25), (24), (19), (18), (18), (2), (1), (1), (1)
Host
Rabbit
(38), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (14), (11), (5), (5), (3), (2), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN350398
454.67 $
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ5 (GIRK4, Kir3.4, KATP-1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 91% identity with rat and mouse sequences.
Specificity Specific for KCNJ5.
Purification Whole serum
Alternative Name KCNJ5
Background Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Tissue specificity: Islets, exocrine pancreas and heart.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: G protein-activated inward rectifier potassium channel 4, GIRK4, Potassium channel, inwardly rectifying subfamily J member 5, Inward rectifier K(+) channel Kir3.4, Heart KATP channel, KATP-1, Cardiac inward rectifier, CIR.
Research Area Cardiovascular, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Ashford, Bond, Blair et al.: "Cloning and functional expression of a rat heart KATP channel." in: Nature, Vol. 370, Issue 6489, pp. 456-9, 1994 (PubMed).

Iizuka, Kubo, Tsunenari et al.: "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel." in: Receptors & channels, Vol. 3, Issue 4, pp. 299-315, 1996 (PubMed).

Schoots, Wilson, Ethier et al.: "Co-expression of human Kir3 subunits can yield channels with different functional properties." in: Cellular signalling, Vol. 11, Issue 12, pp. 871-83, 2000 (PubMed).

Validation Images
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