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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 6 (KCNJ6) (Cytoplasmic Domain) antibody

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Antigen
  • BIR1
  • GIRK-2
  • GIRK2
  • hiGIRK2
  • KATP-2
  • KATP2
  • kcnj6
  • KCNJ7
  • KIR3.2
  • Kir3.2
  • weaver
  • wv
Epitope
Cytoplasmic Domain
21
15
11
8
7
4
3
2
2
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
59
18
15
1
1
Host
Rabbit
47
14
Clonality
Polyclonal
Conjugate
Un-conjugated
4
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
48
38
23
15
8
2
1
1
1
Supplier
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ6 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNJ6.
Purification Whole serum
Alternative Name KCNJ6 (KCNJ6 Antibody Abstract)
Background Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Tissue specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: G protein-activated inward rectifier potassium channel 2, GIRK2, Potassium channel, inwardly rectifying subfamily J member 6, Inward rectifier K(+) channel Kir3.2, KATP-2, BIR1, KATP2, KCNJ7.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Schoots, Wilson, Ethier, Bigras, Hebert, Van Tol: "Co-expression of human Kir3 subunits can yield channels with different functional properties." in: Cellular signalling, Vol. 11, Issue 12, pp. 871-83, 2000

Ferrer, Nichols, Makhina, Salkoff, Bernstein, Gerhard, Wasson, Ramanadham, Permutt: "Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels." in: The Journal of biological chemistry, Vol. 270, Issue 44, pp. 26086-91, 1995

Sakura, Bond, Warren-Perry, Horsley, Kearney, Tucker, Adelman, Turner, Ashcroft: "Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit." in: FEBS letters, Vol. 367, Issue 2, pp. 193-7, 1995

Tsaur, Menzel, Lai, Espinosa, Concannon, Spielman, Hanis, Cox, Le Beau, German: "Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM." in: Diabetes, Vol. 44, Issue 5, pp. 592-6, 1995

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