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Details for Product No. ABIN350400

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) (Cytoplasmic Domain) antibody

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Antigen
Synonyms KIR6.1, uKATP-1, sltr, gnite, slmbr, Kir6.1, AI448900, UKATP1, zkir6.1, si:dkey-183c2.2, kir6.1
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350400
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ8 (Kir6.1, uKATP-1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Appears to be specific for KCNJ8.
Purity whole serum
Alternative Name KCNJ8 (Kir6.1, uKATP-1)
Background Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 8, Potassium channel, inwardly rectifying subfamily J member 8, Inwardly rectifier K(+) channel Kir6.1, uKATP-1.
UniProt Q15842
Application Notes IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Inagaki, Inazawa, Seino: "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)." in: Genomics, Vol. 30, Issue 1, pp. 102-4, 1996 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).

Alternatives for antigen "Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8)", type "Antibodies"
Hosts (14), (1)
Reactivities (12), (6), (6), (1), (1), (1), (1), (1), (1)
Applications (15), (7), (5), (4), (2), (1), (1)
Epitopes (5), (3), (2), (2), (2), (1)
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