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Potassium Inwardly-Rectifying Channel, Subfamily J, Member 8 (KCNJ8) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350400, Supplier: Login to see
Antigen
  • kir6.1
  • KIR6.1
  • uKATP-1
  • AI448900
  • Kir6.1
  • gnite
  • slmbr
  • sltr
  • UKATP1
  • si:dkey-183c2.2
  • zkir6.1
Epitope
Cytoplasmic Domain
19
18
18
18
17
13
3
3
2
2
Reactivity
Human, Rat (Rattus), Mouse (Murine)
48
43
43
2
2
1
1
1
1
1
Host
Rabbit
47
18
1
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
52
37
21
19
18
12
7
1
1
Supplier
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ8 (Kir6.1, uKATP-1) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for KCNJ8.
Purification Whole serum
Alternative Name KCNJ8 (KCNJ8 Antibody Abstract)
Background Function: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 8, Potassium channel, inwardly rectifying subfamily J member 8, Inwardly rectifier K(+) channel Kir6.1, uKATP-1.
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Inagaki, Inazawa, Seino: "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)." in: Genomics, Vol. 30, Issue 1, pp. 102-4, 1996 (PubMed).

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