Potassium Inwardly-Rectifying Channel, Subfamily J, Member 9 (KCNJ9) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350402
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Antigen
Synonyms GIRK3, KIR3.3, 1700085N21Rik, Girk3, Kir3.3, mbGIRK3
Epitope
Cytoplasmic Domain
(3), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(32), (30), (28), (17), (17)
Host
Rabbit
(33), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(20), (14), (8), (5), (2), (1), (1)
Pubmed 3 references available
Quantity 100 µL
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Catalog No. ABIN350402
454.67 $
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Immunogen A synthetic peptide from the cytoplasmic domain of human KCNJ9 (Kir3.3, GIRK3) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNJ9.
Purification Whole serum
Alternative Name KCNJ9
Background Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Tissue specificity: Expressed mainly in the brain, some expression in the skeletal muscle.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: G protein-activated inward rectifier potassium channel 3, GIRK3, Potassium channel, inwardly rectifying subfamily J member 9, Inwardly rectifier K(+) channel Kir3.3.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Schoots, Wilson, Ethier et al.: "Co-expression of human Kir3 subunits can yield channels with different functional properties." in: Cellular signalling, Vol. 11, Issue 12, pp. 871-83, 2000 (PubMed).

Vaughn, Wolford, Prochazka et al.: "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)." in: Biochemical and biophysical research communications, Vol. 274, Issue 2, pp. 302-9, 2000 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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