Potassium Channel, Subfamily K, Member 16 (KCNK16) (AA 10-60) antibody

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Synonyms K2p16.1, TALK-1, TALK1, 4731413G05Rik
AA 10-60
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Quantity 100 μL
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Immunogen A synthetic peptide from aa region 10-60 of human KCNK16 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares about 95% identity with rat and mouse sequences.
Specificity Specific for KCNK16.
Purification Whole serum
Alternative Name KCNK16
Background Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Inhibited by Ba2+, quinine, quinidine, chloroform and halothane. Activated at alkaline pH.
Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 16, TWIK-related alkaline pH-activated K(+) channel 1, 2P domain potassium channel Talk-1, TALK1.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Girard, Duprat, Terrenoire et al.: "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels." in: Biochemical and biophysical research communications, Vol. 282, Issue 1, pp. 249-56, 2001 (PubMed).

Catalog No. ABIN350407
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