KCNK17 (TALK2, TASK4, KCNKH) (C-Term) antibody

Antigen: KCNK17 (TALK2, TASK4, KCNKH)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350408

Additional Information

UniProt: Q96T54

Immunogen: A synthetic peptide from the c-terminal region of human KCNK17 (TALK2, TASK4, KCNKH) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 17, TWIK-related alkaline pH-activated K(+) channel 2, 2P domain potassium channel Talk-2, TWIK-related acid-sensitive K(+) channel 4, KCNK17, TALK2, TASK4.

Specificity: Appears to be specific for KCNK17.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Decher, Maier, Dittrich et al.: "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family." in: FEBS letters, Vol. 492, Issue 1-2, pp. 84-9, 2001 (PubMed).

Girard, Duprat, Terrenoire et al.: "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels." in: Biochemical and biophysical research communications, Vol. 282, Issue 1, pp. 249-56, 2001 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).