Potassium Channel, Subfamily K, Member 17 (KCNK17) (C-Term) antibody

Details for Product No. ABIN350408
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Antigen
Synonyms K2p17.1, TALK-2, TALK2, TASK-4, TASK4
Epitope
C-Term
(3), (1)
Reactivity
Human
(10)
Host
Rabbit
(9), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(10), (8), (1)
Pubmed 4 references available
Quantity 100 µL
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Catalog No. ABIN350408
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of human KCNK17 (TALK2, TASK4, KCNKH) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNK17.
Purification Whole serum
Alternative Name KCNK17
Background Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 17, TWIK-related alkaline pH-activated K(+) channel 2, 2P domain potassium channel Talk-2, TWIK-related acid-sensitive K(+) channel 4, KCNK17, TALK2, TASK4.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Decher, Maier, Dittrich et al.: "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family." in: FEBS letters, Vol. 492, Issue 1-2, pp. 84-9, 2001 (PubMed).

Girard, Duprat, Terrenoire et al.: "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels." in: Biochemical and biophysical research communications, Vol. 282, Issue 1, pp. 249-56, 2001 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

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