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Details for Product No. ABIN350409

KCNK18 (TRESK, KCNKI) (N-Term) antibody

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Mouse (Murine)
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350409
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the n-terminal region of mouse KCNK18 (TRESK, KCNKI) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for KCNK18.
Purity whole serum
Background Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents.
Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI.
UniProt Q6VV64
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Czirjuak, Tuoth, Enyedi: "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 18550-8, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Keshavaprasad, Liu, Au et al.: "Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK." in: Anesthesia and analgesia, Vol. 101, Issue 4, pp. 1042-9, table of contents, 2005 (PubMed).

Czirjuak, Enyedi: "Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK." in: The Journal of biological chemistry, Vol. 281, Issue 21, pp. 14677-82, 2006 (PubMed).