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KCNK18 antibody (Potassium Channel Subfamily K Member 18) (N-Term)

Details for Product anti-KCNK18 Antibody No. ABIN350409, Supplier: Log in to see
Antigen
  • Gm781
  • K2p18.1
  • MGR13
  • TRESK
  • Tresk
  • TRESK-2
  • Tresk-2
  • TRESK2
  • Trik
  • TRIK
Epitope
N-Term
16
16
12
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
32
8
8
Host
Rabbit
32
Clonality
Polyclonal
Conjugate
This KCNK18 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
29
25
24
9
2
2
1
Supplier
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Immunogen A synthetic peptide from the n-terminal region of mouse KCNK18 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNK18.
Purification Whole serum
Alternative Name KCNK18 (KCNK18 Antibody Abstract)
Background Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents.
Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Czirjuak, Enyedi: "Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK." in: The Journal of biological chemistry, Vol. 281, Issue 21, pp. 14677-82, 2006 (PubMed).

Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: "The transcriptional landscape of the mammalian genome. ..." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Keshavaprasad, Liu, Au, Kindler, Cotten, Yost: "Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK." in: Anesthesia and analgesia, Vol. 101, Issue 4, pp. 1042-9, table of contents, 2005 (PubMed).

Czirjuak, Tuoth, Enyedi: "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin." in: The Journal of biological chemistry, Vol. 279, Issue 18, pp. 18550-8, 2004 (PubMed).