Potassium Channel, Subfamily K, Member 2 (KCNK2) (N-Term) antibody

Details for Product No. ABIN350410
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Antigen
Synonyms KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e, A430027H14Rik, AI848635, Trek-1, rTREK1d
Epitope
N-Term
(8), (4), (1), (1), (1)
Reactivity
Human
(11), (8), (3), (1)
Host
Rabbit
(17), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(17), (3), (3), (1)
Pubmed 3 references available
Quantity 100 µL
Options
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Catalog No. ABIN350410
454.67 $
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Immunogen A synthetic peptide from the n-terminal region of human KCNK2 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNK2.
Purification Whole serum
Alternative Name KCNK2
Background Function: Outward rectifying potassium channel. Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore potassium channel TPKC1, Two pore domain potassium channel TREK-1, TREK, TREK1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Patel, Honorue, Lesage et al.: "Inhalational anesthetics activate two-pore-domain background K+ channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 422-6, 1999 (PubMed).

Meadows, Benham, Cairns et al.: "Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel." in: Pflügers Archiv : European journal of physiology, Vol. 439, Issue 6, pp. 714-22, 2000 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

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