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KCNK2 antibody (Potassium Channel, Subfamily K, Member 2) (N-Term)

Details for Product anti-KCNK2 Antibody No. ABIN350410, Supplier: Log in to see
Antigen
  • A430027H14Rik
  • AI848635
  • hTREK-1c
  • hTREK-1e
  • K2p2.1
  • KCNK2
  • rTREK1d
  • TPKC1
  • TREK
  • Trek-1
  • TREK-1
  • TREK1
Epitope
N-Term
21
17
2
1
1
1
Reactivity
Human
26
26
18
3
Host
Rabbit
34
Clonality
Polyclonal
Conjugate
This KCNK2 antibody is un-conjugated
2
2
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
32
4
3
1
Supplier
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Immunogen A synthetic peptide from the n-terminal region of human KCNK2 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNK2.
Purification Whole serum
Alternative Name KCNK2 (KCNK2 Antibody Abstract)
Background Function: Outward rectifying potassium channel. Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 2, Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore potassium channel TPKC1, Two pore domain potassium channel TREK-1, TREK, TREK1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Meadows, Benham, Cairns, Gloger, Jennings, Medhurst, Murdock, Chapman: "Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel." in: Pflügers Archiv : European journal of physiology, Vol. 439, Issue 6, pp. 714-22, 2000 (PubMed).

Patel, Honoré, Lesage, Fink, Romey, Lazdunski: "Inhalational anesthetics activate two-pore-domain background K+ channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 422-6, 1999 (PubMed).