KCNK3 (TASK1, KT3.1) (C-Term) antibody

Antigen: KCNK3 (TASK1, KT3.1)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350411

Additional Information

UniProt: O14649

Immunogen: A synthetic peptide from the c-terminal region of human KCNK3 (TASK1, KT3.1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, TASK, TASK1.

Specificity: Appears to be specific for KCNK3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Duprat, Lesage, Fink et al.: "TASK, a human background K+ channel to sense external pH variations near physiological pH." in: The EMBO journal, Vol. 16, Issue 17, pp. 5464-71, 1997 (PubMed).

Patel, Honorue, Lesage et al.: "Inhalational anesthetics activate two-pore-domain background K+ channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 422-6, 1999 (PubMed).

Lopes, Gallagher, Buck et al.: "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16969-78, 2000 (PubMed).

Ashmole, Goodwin, Stanfield: "TASK-5, a novel member of the tandem pore K+ channel family." in: Pflügers Archiv : European journal of physiology, Vol. 442, Issue 6, pp. 828-33, 2001 (PubMed).