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Details for Product No. ABIN350411

KCNK3 (TASK1, KT3.1) (C-Term) antibody

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Antigen
Epitope
C-Term
Reactivity
Human
Host
Rabbit
Clonality Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350411
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human KCNK3 (TASK1, KT3.1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for KCNK3.
Purity whole serum
Background Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, TASK, TASK1.
UniProt O14649
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Duprat, Lesage, Fink et al.: "TASK, a human background K+ channel to sense external pH variations near physiological pH." in: The EMBO journal, Vol. 16, Issue 17, pp. 5464-71, 1997 (PubMed).

Patel, Honorue, Lesage et al.: "Inhalational anesthetics activate two-pore-domain background K+ channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 422-6, 1999 (PubMed).

Lopes, Gallagher, Buck et al.: "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16969-78, 2000 (PubMed).

Ashmole, Goodwin, Stanfield: "TASK-5, a novel member of the tandem pore K+ channel family." in: Pflügers Archiv : European journal of physiology, Vol. 442, Issue 6, pp. 828-33, 2001 (PubMed).

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