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Potassium Channel, Subfamily K, Member 3 (KCNK3) (AA 250-300) antibody

Details for Product No. ABIN350411
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Antigen
Synonyms si:dkey-164m15.1, K2p3.1, OAT1, PPH4, TASK, TASK-1, TBAK1, cTBAK-1, Task-1, rTASK, KCNK3
Epitope
AA 250-300
(20), (18), (3), (1), (1)
Reactivity
Human
(34), (19), (16), (13), (13), (12), (1)
Host
Rabbit
(20), (18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(29), (19), (18), (10), (9), (4), (3)
Pubmed 4 references available
Quantity 100 µL
Options
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Catalog No. ABIN350411
454.67 $
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Immunogen A synthetic peptide from aa region 250-300 of human KCNK3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNK3.
Purification Whole serum
Alternative Name KCNK3
Background Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.
Tissue specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, TASK, TASK1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Duprat, Lesage, Fink et al.: "TASK, a human background K+ channel to sense external pH variations near physiological pH." in: The EMBO journal, Vol. 16, Issue 17, pp. 5464-71, 1997 (PubMed).

Patel, Honorue, Lesage et al.: "Inhalational anesthetics activate two-pore-domain background K+ channels." in: Nature neuroscience, Vol. 2, Issue 5, pp. 422-6, 1999 (PubMed).

Lopes, Gallagher, Buck et al.: "Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3." in: The Journal of biological chemistry, Vol. 275, Issue 22, pp. 16969-78, 2000 (PubMed).

Ashmole, Goodwin, Stanfield: "TASK-5, a novel member of the tandem pore K+ channel family." in: Pflügers Archiv : European journal of physiology, Vol. 442, Issue 6, pp. 828-33, 2001 (PubMed).

Validation Images
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