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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Potassium Channel, Subfamily K, Member 5 (KCNK5) (C-Term) antibody
|Synonyms||TASK2, K2p5.1, TASK-2, FLJ11035, MGC63921, zgc:63921, task2, k2p5.1, task-2, KCNK5|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||KCNK5 (TASK2)|
|Immunogen||A synthetic peptide from the c-terminal region of human KCNK5 (TASK2) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||Function: pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations. Inhibited by quinine, quinidine and external acidification. Tissue specificity: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2, KCNK5, TASK2.|
|Specificity||Appears to be specific for KCNK5.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Reyes, Duprat, Lesage et al.: "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney." in: The Journal of biological chemistry, Vol. 273, Issue 47, pp. 30863-9, 1998 (PubMed).
Niemeyer, Cid, Valenzuela et al.: "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity." in: Molecular membrane biology, Vol. 20, Issue 2, pp. 185-91, 2003 (PubMed).
Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).
Gierten, Ficker, Bloehs et al.: "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein." in: British journal of pharmacology, Vol. 154, Issue 8, pp. 1680-90, 2008 (PubMed).
Daub, Olsen, Bairlein et al.: "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." in: Molecular cell, Vol. 31, Issue 3, pp. 438-48, 2008 (PubMed).
|Reactivities||Human (8), Mouse (Murine) (6), Rat (Rattus) (4), Cow (Bovine) (2), Dog (Canine) (2), Cat (Feline) (1), Chicken (1), Rabbit (1)|
|Applications||Western Blotting (WB) (10), ELISA (6), Immunofluorescence (IF) (2), Immunohistochemistry (IHC) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1), Immunoprecipitation (IP) (1)|
|Epitopes||C-Term (1), Center (1), Internal Region (1)|