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Potassium Channel, Subfamily K, Member 5 (KCNK5) (C-Term) antibody

Details for Product No. ABIN350413
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Antigen
Synonyms kcnk5, zgc:63921, task2, k2p5.1, task-2, K2p5.1, TASK-2, TASK2
Epitope
C-Term
(2), (1), (1), (1), (1), (1)
Reactivity
Human
(8), (4), (2), (1), (1), (1)
Host
Rabbit
(9), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(9), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350413
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of human KCNK5 (TASK2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNK5.
Purification Whole serum
Alternative Name KCNK5
Background Function: pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations. Inhibited by quinine, quinidine and external acidification.
Tissue specificity: Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 5, Acid-sensitive potassium channel protein TASK-2, TWIK-related acid-sensitive K(+) channel 2, KCNK5, TASK2.
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Reyes, Duprat, Lesage et al.: "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney." in: The Journal of biological chemistry, Vol. 273, Issue 47, pp. 30863-9, 1998 (PubMed).

Niemeyer, Cid, Valenzuela et al.: "Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity." in: Molecular membrane biology, Vol. 20, Issue 2, pp. 185-91, 2003 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Gierten, Ficker, Bloehs et al.: "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein." in: British journal of pharmacology, Vol. 154, Issue 8, pp. 1680-90, 2008 (PubMed).

Daub, Olsen, Bairlein et al.: "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." in: Molecular cell, Vol. 31, Issue 3, pp. 438-48, 2008 (PubMed).

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