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Potassium Channel Subfamily K Member 6 (KCNK6) (C-Term) antibody

Details for Product No. ABIN350415, Supplier: Log in to see
Antigen
  • D7Ertd764e
  • im:7152114
  • K2p6.1
  • KCNK8
  • TOSS
  • Toss
  • Twik-2
  • TWIK-2
  • TWIK2
  • Twik2
  • zgc:110418
Epitope
C-Term
21
18
3
Reactivity
Rat (Rattus)
28
Host
Rabbit
28
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
25
18
2
1
Supplier
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Immunogen A synthetic peptide from the c-terminal region of rat KCNK6 (TOSS, TWIK2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNK6.
Purification Whole serum
Alternative Name KCNK6 (KCNK6 Antibody Abstract)
Background Function: Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions. Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.
Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, TOSS, TWIK2.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Okazaki, Furuno, Kasukawa, Adachi, Bono, Kondo, Nikaido, Osato, Saito, Suzuki, Yamanaka, Kiyosawa, Yagi, Tomaru, Hasegawa, Nogami, Schönbach, Gojobori, Baldarelli, Hill, Bult, Hume, Quackenbush et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. ..." in: Nature, Vol. 420, Issue 6915, pp. 563-73, 2002 (PubMed).

Kawai, Shinagawa, Shibata, Yoshino, Itoh, Ishii, Arakawa, Hara, Fukunishi, Konno, Adachi, Fukuda, Aizawa, Izawa, Nishi, Kiyosawa, Kondo, Yamanaka, Saito, Okazaki, Gojobori, Bono, Kasukawa, Saito, Kadota, Matsuda, Ashburner, Batalov, Casavant, Fleischmann,: "Functional annotation of a full-length mouse cDNA collection." in: Nature, Vol. 409, Issue 6821, pp. 685-90, 2001 (PubMed).

Patel, Maingret, Magnone, Fosset, Lazdunski, Honorue: "TWIK-2, an inactivating 2P domain K+ channel." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28722-30, 2000 (PubMed).

Shibata, Itoh, Aizawa, Nagaoka, Sasaki, Carninci, Konno, Akiyama, Nishi, Kitsunai, Tashiro, Itoh, Sumi, Ishii, Nakamura, Hazama, Nishine, Harada, Yamamoto, Matsumoto, Sakaguchi, Ikegami, Kashiwagi et al.: "RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. ..." in: Genome research, Vol. 10, Issue 11, pp. 1757-71, 2000 (PubMed).

Carninci, Hayashizaki: "High-efficiency full-length cDNA cloning." in: Methods in enzymology, Vol. 303, pp. 19-44, 1999 (PubMed).