Potassium Channel Subfamily K Member 6 (KCNK6) (C-Term) antibody

Details for Product No. ABIN350415
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Antigen
Synonyms K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, Twik2, Twik-2, im:7152114, zgc:110418
Epitope
C-Term
(3), (3), (2)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(8), (1), (1)
Host
Sheep
(9)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(9), (1), (1)
Pubmed 5 references available
Catalog no. ABIN350415
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the c-terminal region of rat KCNK6 (TOSS, TWIK2) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CACNG8.
Purification whole serum
Alternative Name KCNK6 (TOSS, TWIK2)
Background Function: Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions. Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium.
Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, TOSS, TWIK2.
UniProt Q8VHW5
Research Area Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Carninci, Hayashizaki: "High-efficiency full-length cDNA cloning." in: Methods in enzymology, Vol. 303, pp. 19-44, 1999 (PubMed).

Patel, Maingret, Magnone et al.: "TWIK-2, an inactivating 2P domain K+ channel." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28722-30, 2000 (PubMed).

Shibata, Itoh, Aizawa et al.: "RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." in: Genome research, Vol. 10, Issue 11, pp. 1757-71, 2000 (PubMed).

Kawai, Shinagawa, Shibata et al.: "Functional annotation of a full-length mouse cDNA collection." in: Nature, Vol. 409, Issue 6821, pp. 685-90, 2001 (PubMed).

Okazaki, Furuno, Kasukawa et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." in: Nature, Vol. 420, Issue 6915, pp. 563-73, 2002 (PubMed).

Hosts (9)
Reactivities (8), (1), (1)
Applications (9), (1), (1)
Epitopes (3), (3), (2)
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