Potassium Channel Subfamily K Member 6 (KCNK6) (C-Term) antibody

Antigen: Potassium Channel Subfamily K Member 6 (KCNK6)

Synonyms: Twik2, Twik-2, TOSS, KCNK8, TWIK2, K2p6.1, TWIK-2, FLJ12282, MGC110418, im:7152114

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350415

Additional Information

Alternative name: KCNK6 (TOSS, TWIK2)

UniProt: Q9ERU5

Immunogen: A synthetic peptide from the c-terminal region of rat KCNK6 (TOSS, TWIK2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Function: Exhibits outward rectification in a physiological K+ gradient and mild inward rectification in symmetrical K+ conditions. Inhibited by internal acidification and, to a small degree, by zinc. Not inhibited by quinine, quinidine or barium. Tissue specificity: Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, TOSS, TWIK2.

Specificity: Appears to be specific for KCNK6.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Carninci, Hayashizaki: "High-efficiency full-length cDNA cloning." in: Methods in enzymology, Vol. 303, pp. 19-44, 1999 (PubMed).

Patel, Maingret, Magnone et al.: "TWIK-2, an inactivating 2P domain K+ channel." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28722-30, 2000 (PubMed).

Shibata, Itoh, Aizawa et al.: "RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." in: Genome research, Vol. 10, Issue 11, pp. 1757-71, 2000 (PubMed).

Kawai, Shinagawa, Shibata et al.: "Functional annotation of a full-length mouse cDNA collection." in: Nature, Vol. 409, Issue 6821, pp. 685-90, 2001 (PubMed).

Okazaki, Furuno, Kasukawa et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." in: Nature, Vol. 420, Issue 6915, pp. 563-73, 2002 (PubMed).