Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1) (N-Term) antibody

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Synonyms KCNMB1, BKbeta1, K(VCA)beta, SLO-BETA, hbeta1, hslo-beta, k(VCA)beta-1, slo-beta-1, BKBETA
(17), (13), (2), (2), (1), (1), (1), (1)
Human, Rat (Rattus), Mouse (Murine)
(34), (16), (14)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(23), (13), (10), (4), (3), (1), (1)
Pubmed 5 references available
Quantity 100 μL
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of KCNMB1 (Maxi K channel subunit beta-1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNMB1.
Purification Whole serum
Alternative Name KCNMB1 (KCNMB1 Antibody Abstract)
Background Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. Also known as: Calcium-activated potassium channel subunit beta-1, Calcium-activated potassium channel, subfamily M subunit beta-1, Calcium-activated potassium channel subunit beta, Maxi K channel subunit beta-1, BK channel subunit beta-1, BKbeta1, BKbeta, Hbeta1, K(VCA)beta-1, Slo-beta-1, Slo-beta, Charybdotoxin receptor subunit beta-1.
Research Area Ion Channels
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Fernuandez-Fernuandez, Tomuas, Vuazquez et al.: "Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension." in: The Journal of clinical investigation, Vol. 113, Issue 7, pp. 1032-9, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Mazzone, Kaiser, Buxton: "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy." in: Proceedings of the Western Pharmacology Society, Vol. 45, pp. 184-6, 2002 (PubMed).

Tseng-Crank, Godinot, Johansen et al.: "Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 17, pp. 9200-5, 1996 (PubMed).

Meera, Wallner, Jiang et al.: "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels." in: FEBS letters, Vol. 382, Issue 1-2, pp. 84-8, 1996 (PubMed).

Catalog No. ABIN350419
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