Maxi K Channel Subunit beta-4 (KCNMB4) (C-Term) antibody

Antigen: Maxi K Channel Subunit beta-4 (KCNMB4)

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350422

Additional Information

Alternative name: KCNMB4 (Maxi K channel subunit beta-4) (c-terminal region)

Swiss-Prot: Q9ESK8

Immunogen: A synthetic peptide from the c-terminal region of rat KCNMB4 (Maxi K channel subunit beta-4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.

Format: Lyophilized

Description: Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Calcium-activated potassium channel subunit beta-4, Calcium-activated potassium channel, subfamily M subunit beta-4, Maxi K channel subunit beta-4, BK channel subunit beta-4, BKbeta4, K(VCA)beta-4, Slo-beta-4, Charybdotoxin receptor subunit beta-4.

Specificity: Appears to be specific for KCNMB4.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Weiger, Holmqvist, Levitan et al.: "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 10, pp. 3563-70, 2000 (PubMed).