KCNN1 (SK, SK1) (C-Term) antibody

Antigen: KCNN1 (SK, SK1)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN350423

Additional Information

UniProt: Q92952

Immunogen: A synthetic peptide from c-terminal region of human KCNN1 (SK, SK1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Small conductance calcium-activated potassium channel protein 1, SK1, SK.

Specificity: Appears to be specific for KCNN1.

Application Details

Application Notes: IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Koehler, Hirschberg, Bond et al.: "Small-conductance, calcium-activated potassium channels from mammalian brain." in: Science (New York, N.Y.), Vol. 273, Issue 5282, pp. 1709-14, 1996 (PubMed).

Joiner, Wang, Tang et al.: "hSK4, a member of a novel subfamily of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 11013-8, 1997 (PubMed).

Litt, LaMorticella, Bond et al.: "Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)." in: Cytogenetics and cell genetics, Vol. 86, Issue 1, pp. 70-3, 1999 (PubMed).

Hoffert, Pisitkun, Wang et al.: "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 7159-64, 2006 (PubMed).

Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).