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KCNN1 antibody (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 1) (C-Term)

Details for Product anti-KCNN1 Antibody No. ABIN350423, Supplier: Log in to see
Antigen
  • KCNN1
  • kcnn1
  • si:ch211-200a16.1
  • sk1
  • hsk1
  • skca1
  • MGC145919
  • KCa2.1
  • SK1
  • SKCA1
  • hSK1
  • AI854248
Epitope
C-Term
18
16
2
2
1
Reactivity
Human
30
5
5
1
1
1
Host
Rabbit
30
Clonality
Polyclonal
Conjugate
This KCNN1 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
25
19
2
1
Supplier
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Immunogen A synthetic peptide from c-terminal region of human KCNN1 (SK, SK1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for KCNN1.
Purification Whole serum
Alternative Name KCNN1 (KCNN1 Antibody Abstract)
Background Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Small conductance calcium-activated potassium channel protein 1, SK1, SK.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).

Hoffert, Pisitkun, Wang et al.: "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 18, pp. 7159-64, 2006 (PubMed).

Litt, LaMorticella, Bond et al.: "Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)." in: Cytogenetics and cell genetics, Vol. 86, Issue 1, pp. 70-3, 1999 (PubMed).

Joiner, Wang, Tang et al.: "hSK4, a member of a novel subfamily of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 11013-8, 1997 (PubMed).

Koehler, Hirschberg, Bond et al.: "Small-conductance, calcium-activated potassium channels from mammalian brain." in: Science (New York, N.Y.), Vol. 273, Issue 5282, pp. 1709-14, 1996 (PubMed).