Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) (C-Term) antibody

Details for Product No. ABIN350426
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Antigen
Synonyms KCa3.1, IK1, IKCA1, KCA4, SK4, hIKCa1, hKCa4, hSK4, rKCNN4c, rSK4, SKCas, mIKCa1
Epitope
C-Term
(14), (4), (3), (3), (2), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(50), (27), (25), (13), (1)
Host
Rabbit
(46), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(30), (10), (10), (8), (7), (4), (2), (1)
Pubmed 5 references available
Quantity 100 μL
Options
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Catalog No. ABIN350426
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of human KCNN4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for KCNN4.
Purification Whole serum
Alternative Name KCNN4
Background Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Widely expressed in non-excitable tissues. Also known as: Intermediate conductance calcium-activated potassium channel protein 4, SK4, KCa4, IKCa1, IK1, IK1, IKCA1, KCA4, SK4.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Ishii, Silvia, Hirschberg et al.: "A human intermediate conductance calcium-activated potassium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 21, pp. 11651-6, 1997 (PubMed).

Joiner, Wang, Tang et al.: "hSK4, a member of a novel subfamily of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 11013-8, 1997 (PubMed).

Logsdon, Kang, Togo et al.: "A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 32723-6, 1998 (PubMed).

Wulff, Gutman, Cahalan et al.: "Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32040-5, 2001 (PubMed).

Srivastava, Li, Lin et al.: "The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3630-8, 2005 (PubMed).

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