Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) (C-Term) antibody

Antigen: Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4)

Synonyms: IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1, mIKCa1, rSK4, rKCNN4c, MGC156636, MGC142940

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350426

Additional Information

Alternative name: KCNN4 (SK4)

UniProt: O15554

Immunogen: A synthetic peptide from the c-terminal region of human KCNN4 (SK4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.

Format: Lyophilized

Description: Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Widely expressed in non-excitable tissues. Also known as: Intermediate conductance calcium-activated potassium channel protein 4, SK4, KCa4, IKCa1, IK1, IK1, IKCA1, KCA4, SK4.

Specificity: Appears to be specific for KCNN4.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Ishii, Silvia, Hirschberg et al.: "A human intermediate conductance calcium-activated potassium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 21, pp. 11651-6, 1997 (PubMed).

Joiner, Wang, Tang et al.: "hSK4, a member of a novel subfamily of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 11013-8, 1997 (PubMed).

Logsdon, Kang, Togo et al.: "A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 32723-6, 1998 (PubMed).

Wulff, Gutman, Cahalan et al.: "Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32040-5, 2001 (PubMed).

Srivastava, Li, Lin et al.: "The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3630-8, 2005 (PubMed).