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Details for Product No. ABIN350426

Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) (C-Term) antibody

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Antigen
Synonyms IK1, SK4, KCA4, hSK4, IKCA1, hKCa4, KCa3.1, hIKCa1, SKCas, mIKCa1, rKCNN4c, rSK4
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350426
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human KCNN4 (SK4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Appears to be specific for KCNN4.
Purity whole serum
Alternative Name KCNN4 (SK4)
Background Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Widely expressed in non-excitable tissues. Also known as: Intermediate conductance calcium-activated potassium channel protein 4, SK4, KCa4, IKCa1, IK1, IK1, IKCA1, KCA4, SK4.
UniProt O15554
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Ishii, Silvia, Hirschberg et al.: "A human intermediate conductance calcium-activated potassium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 21, pp. 11651-6, 1997 (PubMed).

Joiner, Wang, Tang et al.: "hSK4, a member of a novel subfamily of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 20, pp. 11013-8, 1997 (PubMed).

Logsdon, Kang, Togo et al.: "A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 32723-6, 1998 (PubMed).

Wulff, Gutman, Cahalan et al.: "Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32040-5, 2001 (PubMed).

Srivastava, Li, Lin et al.: "The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3630-8, 2005 (PubMed).

Alternatives for antigen "Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4)", type "Antibodies"
Hosts (45), (3)
Reactivities (46), (26), (22), (13), (1)
Applications (28), (12), (10), (10), (6), (4), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (7), (3), (3), (1)
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