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Potassium Channel, Subfamily T, Member 1 (KCNT1) (4th Cytoplasmic Domain) antibody

Details for Product No. ABIN350427
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Antigen
Synonyms slack, Slo2.2, MGC146594, MGC172997, EIEE14, ENFL5, KCa4.1, SLACK, bA100C15.2, C030030G16Rik, Slack, mKIAA1422, slo2, rSlo2
Epitope
4th Cytoplasmic Domain
(21), (8), (1)
Reactivity
Human
(31), (13), (13), (2)
Host
Rabbit
(23), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(30), (28), (18), (9), (3), (2), (2), (2), (1)
Pubmed 2 references available
Quantity 100 µL
Options
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Catalog No. ABIN350427
454.67 $
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Immunogen A synthetic peptide from the 4th cytoplasmic domain of human Potassium channel subfamily T member 1 (KCNT1, KCa4.1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in monkey.
Specificity Specific for KCNT1.
Purification Whole serum
Alternative Name KCNT1
Background Function: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+.
Subcellular location: Membrane, Multi-pass membrane protein
Tissue specificity: Testis-specific. Mainly expressed in spermatocytes. Detected in brain and brainstem, in vestibular and oculomotor nuclei, the medial nucleus of the trapezoid in the auditory system, inolfactory bulb, red nucleus, and deep cerebellar nuclei. Detected in thalamus, substantia nigra, and amygdala (at protein level). Highly expressed in the brain and kidney. Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. Also known as: Potassium channel subfamily T member 1, KCa4.1, SLACK.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 1, pp. 65-73, 2000 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

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