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Details for Product No. ABIN350427

Potassium Channel, Subfamily T, Member 1 (KCNT1) (4th Cytoplasmic Domain) antibody

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Antigen
Synonyms SLACK, EIEE14, ENFL5, KCa4.1, bA100C15.2, Slack, rSlo2, slo2, mKIAA1422, C030030G16Rik, slack, Slo2.2, MGC146594, MGC172997
Epitope
»Alternatives 4th Cytoplasmic Domain
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350427
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic domain of human Potassium channel subfamily T member 1 (KCNT1, KCa4.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in monkey.
Specificity Appears to be specific for KCNT1.
Purity whole serum
Alternative Name KCNT1 (KCa4.1)
Background Function: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K+. May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca2+ or Mg2+.
Subcellular location: Membrane, Multi-pass membrane protein
Tissue specificity: Testis-specific. Mainly expressed in spermatocytes. Detected in brain and brainstem, in vestibular and oculomotor nuclei, the medial nucleus of the trapezoid in the auditory system, inolfactory bulb, red nucleus, and deep cerebellar nuclei. Detected in thalamus, substantia nigra, and amygdala (at protein level). Highly expressed in the brain and kidney. Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. Also known as: Potassium channel subfamily T member 1, KCa4.1, SLACK.
UniProt Q5JUK3
Application Notes IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Nagase, Kikuno, Ishikawa et al.: "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 1, pp. 65-73, 2000 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Alternatives for antigen "Potassium Channel, Subfamily T, Member 1 (KCNT1)", type "Antibodies"
Hosts (13), (6)
Reactivities (11), (10), (9)
Applications (12), (11), (7), (4), (2), (2), (2), (2), (1)
Epitopes (7), (4)
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