Potassium Channel, Subfamily T, Member 2 (KCNT2) (4th cytoplasmic domain) antibody

Antigen: Potassium Channel, Subfamily T, Member 2 (KCNT2)

Synonyms: SLICK, KCa4.2, SLO2.1, MGC119610, MGC119611, MGC119612, MGC119613, RP11-58O13.1, Slick, E330038N15Rik

Epitope: 4th cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350428

Additional Information

Alternative name: KCNT2 (SLICK) (4th cytoplasmic domain)

Swiss-Prot: Q6UVM3

Immunogen: A synthetic peptide from the 4th cytoplasmic domain of Potassium channel subfamily T member 2 (KCNT2, SLICK) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.

Format: Lyophilized

Description: FUCNTION: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. Subcellular location: Cell membrane; Multi-pass membrane protein Also known as: Potassium channel subfamily T member 2, SLICK, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1.

Specificity: Appears to be specific for KCNT2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Bhattacharjee, Joiner, Wu et al.: "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 37, pp. 11681-91, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Santi, Ferreira, Yang et al.: "Opposite regulation of Slick and Slack K+ channels by neuromodulators." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 19, pp. 5059-68, 2006 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Sjoeblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).