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Potassium Channel, Subfamily T, Member 2 (KCNT2) (4th Cytoplasmic Domain) antibody

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Antigen
  • E330038N15Rik
  • KCa4.2
  • SLICK
  • Slick
  • SLO2.1
Epitope
4th Cytoplasmic Domain
38
17
16
2
Reactivity
Human, Rat (Rattus), Mouse (Murine)
55
53
36
2
Host
Rabbit
43
34
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
63
57
37
21
15
15
11
8
2
2
1
1
Supplier
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Immunogen A synthetic peptide from the 4th cytoplasmic domain of Potassium channel subfamily T member 2 (KCNT2, SLICK) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for KCNT2.
Purification Whole serum
Alternative Name KCNT2 (KCNT2 Antibody Abstract)
Background FUCNTION: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.
Subcellular location: Cell membrane, Multi-pass membrane protein Also known as: Potassium channel subfamily T member 2, SLICK, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Santi, Ferreira, Yang, Gazula, Butler, Wei, Kaczmarek, Salkoff: "Opposite regulation of Slick and Slack K+ channels by neuromodulators." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 19, pp. 5059-68, 2006 (PubMed).

Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Bhattacharjee, Joiner, Wu, Yang, Sigworth, Kaczmarek: "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 37, pp. 11681-91, 2003 (PubMed).